Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors

O A Ibrahimi; L Wu; K Zhao; Z Y Zhang

doi:10.1016/s0960-894x(00)00019-6

Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors

Bioorg Med Chem Lett. 2000 Mar 6;10(5):457-60. doi: 10.1016/s0960-894x(00)00019-6.

Authors

O A Ibrahimi¹, L Wu, K Zhao, Z Y Zhang

Affiliation

¹ Department of Chemistry, New York University, New York, 10003, USA.

PMID: 10743947
DOI: 10.1016/s0960-894x(00)00019-6

Abstract

Nonpeptidyl aryloxymethylphosphonates were prepared and evaluated as protein tyrosine phosphatase inhibitors. The results suggest that aryloxymethylphosphonates are effective nonhydrolyzable phosphotyrosine surrogates and provide further insight into the molecular mechanisms by which phosphate mimics inhibit phosphatase function.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Crystallography, X-Ray
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
Organophosphorus Compounds / chemical synthesis*
Organophosphorus Compounds / pharmacology
Protein Tyrosine Phosphatases / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Organophosphorus Compounds
Protein Tyrosine Phosphatases